2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W357818
    Glycinexylidide
    Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local agent that can suppress or relieve pain, that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease.
    Glycinexylidide
  • HY-143963S
    Irbesartan impurity 20-d4
    Irbesartan impurity 20-d4 is the deuterium labeled Irbesartan impurity 20[1]. Irbesartan impurity 20-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Irbesartan impurity 20-d<sub>4</sub>
  • HY-149548
    2,3-Dinor-8-iso prostaglandin F1α
    2,3-Dinor-8-iso prostaglandin F1α is an isoprostanoid that can be used as a biomarker to assess psychological stress.
    2,3-Dinor-8-iso prostaglandin F1α
  • HY-143980S
    Losartan impurity 21-d4
    Losartan impurity 21-d4 is the deuterium labeled Losartan impurity 21[1]. Losartan impurity 21-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Losartan impurity 21-d<sub>4</sub>
  • HY-101416R
    Vanilpyruvic acid (Standard)
    Vanilpyruvic acid (Standard)
  • HY-12781S
    Desbutyl Lumefantrine-d9
    Desbutyl Lumefantrine-d9 is the deuterium labeled euterium labeled, which is a metabolite of Lumefantrine.
    Desbutyl Lumefantrine-d<sub>9</sub>
  • HY-130569S1
    7-Hydroxymethotrexate-d3
    7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d<sub>3</sub>
  • HY-135407S
    N-Desethyl Oxybutynin-d5 hydrochloride
    N-Desethyl Oxybutynin-d5 (hydrochloride) is deuterium labeled N-Desethyl Oxybutynin hydrochloride. N-Desethyl Oxybutynin is the the active metabolite Oxybutynin. Oxybutynin is an anticholinergic agent that inhibits voltage-dependent K+ channels[1].
    N-Desethyl Oxybutynin-d<sub>5</sub> hydrochloride
  • HY-W059917
    AP24600
    AP24600 is an inactive metabolite of Ponatinib.
    AP24600
  • HY-100639R
    Roflumilast N-oxide (Standard)
    Roflumilast N-oxide (Standard)
  • HY-118116
    bicyclo-PGE2
    bicyclo-PGE2 (bicyclo-PGEM) is a stable decomposition product of PGE2 and 13, 14-dihydro-15-ketone PGE2.
    bicyclo-PGE2
  • HY-Z2106S
    Vonoprazan impurity 11-d5 fumarate
    Vonoprazan impurity 11-d5 (fumarate) is deuterium labeled 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methyl)-N-methylmethanamine (Vonoprazan Impurity).
    Vonoprazan impurity 11-d<sub>5</sub> fumarate
  • HY-121345
    Homobaldrinal
    Homobaldrinal is a decomposition product of Valepotriate (HY-N0718). Homobaldrinal exhibits genotoxic activity in the Salmonella/microsome test.
    Homobaldrinal
  • HY-169463
    11-Hydroxy cannabinol
    11-Hydroxy cannabinol (Compound 5b) is an active metabolite of Cannabinol.
    11-Hydroxy cannabinol
  • HY-15550R
    4'-Hydroxy diclofenac (Standard)
    4'-Hydroxy diclofenac (Standard) is the analytical standard of 4'-Hydroxy diclofenac. This product is intended for research and analytical applications. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties.
    4'-Hydroxy diclofenac (Standard)
  • HY-133668R
    Monoethyl phthalate (Standard)
    Sulfamonomethoxine (sodium) (Standard) is the analytical standard of Sulfamonomethoxine (sodium). This product is intended for research and analytical applications. Sulfamonomethoxine sodium is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
    Monoethyl phthalate (Standard)
  • HY-135374
    (3R,5S)-Atorvastatin sodium
    (3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    (3R,5S)-Atorvastatin sodium
  • HY-114976
    S-Allylmercapturic acid
    S-Allylmercapturic acid is a biomarker of food intake (BFIs) for garlic consumption.
    S-Allylmercapturic acid
  • HY-145461
    Hydroxy lenalidomide
    Hydroxy lenalidomide (5-Hydroxy lenalidomide) is a metabolite of lenalidomide that is present as a minor component in plasma and excreta, accounting for less than 5% of the total radioactivity, following oral administration of lenalidomide in healthy male subjects.
    Hydroxy lenalidomide
  • HY-119696S
    MTIC-d3
    MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the agent’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1].
    MTIC-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity